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1

Protein tyrosine phosphatase 1B inhibitors for diabetes

Johnson, Theodore O., Ermolieff, Jacques, Jirousek, Michael R.

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 879 KB

english, 2002

2

The protein kinase C β–specific inhibitor LY379196 blocks TPA-induced monocytic differentiation of HL60 cells the protein kinase C β–specific inhibitor LY379196 blocks TPA-induced monocytic differentiation of HL60 cells

Eric D. Slosberg, Yao Yao, Fay Xing, Amy Ikui, Michael R. Jirousek, I. Bernard Weinstein

Journal:

Molecular Carcinogenesis

Year:

2000

Language:

english

File:

PDF, 253 KB

english, 2000

3

ChemInform Abstract: Synthesis of Fluorinated Macrocyclic Bis(indolyl)maleimides as Potential 19F NMR Probes for Protein Kinase C.

Peter G. Goekjian, Guo-Zhang Wu, Shi Chen, Lanxin Zhou, Michael R. Jirousek, James R. Gillig, Lawrence M. Ballas, Jeffrey T. Dixon

Journal:

Year:

1999

File:

PDF, 30 KB

1999

4

ChemInform Abstract: Synthesis of Indole-Ring Fluorine-Labeled Analogues of LY333531, an Isoform-Selective Inhibitor of Protein Kinase C.

Peter G. Goekjian, Priscilla Lugo-Mas, Stacy L. Cable, John O. Cole, James W. White, Dale J. Thompson, Tamara P. Dudley, Michael R. Jirousek, Jeffrey T. Dixon, Lawrence M. Ballas

Journal:

Year:

1999

File:

PDF, 30 KB

1999

5

ChemInform Abstract: Protein Kinase C in the Treatment of Disease: Signal Transduction Pathways, Inhibitors, and Agents in Development

Peter G. Goekjian, Michael R. Jirousek

Journal:

Year:

1999

File:

PDF, 25 KB

1999

6

ChemInform Abstract: A Practical and Efficient Intramolecular Michael Addition of Ureas to α,β-Unsaturated Esters.

Zhili Xin, Zhonghua Pei, Tom von Geldem, Michael Jirousek

Journal:

Year:

2000

File:

PDF, 30 KB

2000

7

Acyclic N-(Azacycloalkyl)bisindolylmaleimides: Isozyme Selective Inhibitors of PKCβ.

Margaret M. Faul, James R. Gillig, Michael R. Jirousek, Lawrence M. Ballas, Theo Schotten, Astrid Kahl, Michael Mohr

Journal:

Year:

2003

File:

PDF, 92 KB

2003

8

Photo-induced oxidation of N-vinylcarbazole in a functionalized oil-in-water microemulsion

Carole K. Grätzel, Marie Jirousek, Michael Grätzel

Journal:

Colloids and Surfaces

Year:

1985

Language:

english

File:

PDF, 537 KB

english, 1985

9

Accelerated decomposition of active phosphates on TiO2 surfaces

Carole K. Grätzel, Marie Jirousek, Michael Grätzel

Journal:

Journal of Molecular Catalysis

Year:

1987

Language:

english

File:

PDF, 439 KB

english, 1987

10

Decomposition of organophosphorus compounds on photoactivated TiO2 surfaces

Carole K. Grätzel, Marie Jirousek, Michael Grätzel

Journal:

Journal of Molecular Catalysis

Year:

1990

Language:

english

File:

PDF, 693 KB

english, 1990

11

Rapid mineralisation of organophosphonates by visible light-enhanced peroxidase action of iron(III) complexes

Yoshio Inouye, Marie Jirousek, Carole K. Grätzel, Michael Grätzel

Journal:

Journal of Molecular Catalysis

Year:

1991

Language:

english

File:

PDF, 403 KB

english, 1991

12

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

Jean E. Bemis, Chi B. Vu, Roger Xie, Joseph J. Nunes, Pui Yee Ng, Jeremy S. Disch, Jill C. Milne, David P. Carney, Amy V. Lynch, Lei Jin, Jesse J. Smith, Siva Lavu, Andre Iffland, Michael R. Jirousek,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 200 KB

english, 2009

13

Synthesis of indole-ring fluorine-labeled analogs of LY333531, an isoform-selective inhibitor of protein kinase C

Peter G. Goekjian, Priscilla Lugo-Mas, Stacy L. Cable, John O. Cole, James W. White, Dale J. Thompson, Tamara P. Dudley, Michael R. Jirousek, Jeffrey T. Dixon, Lawrence M. Ballas

Journal:

Journal of Fluorine Chemistry

Year:

1999

Language:

english

File:

PDF, 153 KB

english, 1999

14

A synthesis or indolizidines related to castanospermine and swainsonine.

Michael R. Jirousek, Adrian W-H. Cheung, Robert E. Babine, Philip M. Sass, Steven R. Schow, Michael M. Wick

Journal:

Tetrahedron Letters

Year:

1993

File:

PDF, 323 KB

1993

15

A practical and efficient intramolecular Michael addition of ureas to α,β-unsaturated esters

Zhili Xin, Zhonghua Pei, Tom von Geldem, Michael Jirousek

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 136 KB

english, 2000

16

Synthesis and biological evaluation of a series of HIV-1 protease inhibitors

Michael P. Trova, Robert E. Babine, Randal A. Byrn, Wellington T. Casscles Jr., Richard C. Hastings, Grace C. Hsu, Michael R. Jirousek, Bernard D. Johnson, Suresh S. Kerwar, Steven R. Schow, Allan Wis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 476 KB

english, 1993

17

Structure activity studies on pseudo-symmetrical HIV-1 protease inhibitors

Robert E. Babine, Nan Zhang, Steven R. Schow, Michael R. Jirousek, Bernard D. Johnson, Suresh S. Kerwar, Parimal R. Desai, Randal A. Byrn, Richard C. Hastings, Michael M. Wick

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 374 KB

english, 1993

18

Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ

Margaret M Faul, James R Gillig, Michael R Jirousek, Lawrence M Ballas, Theo Schotten, Astrid Kahl, Michael Mohr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 161 KB

english, 2003

19

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

Zhonghua Pei, Xiaofeng Li, Gang Liu, Cele Abad-Zapatero, Tom Lubben, Tianyuan Zhang, Stephen J. Ballaron, Charles W. Hutchins, James M. Trevillyan, Michael R. Jirousek

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 211 KB

english, 2003

20

Synthesis of bisindolylmaleimides using a palladium catalyzed cross-coupling reaction

David A. Neel, Michael R. Jirousek, John H. McDonald III

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 250 KB

english, 1998

21

Photovoltaic characterization of dye-sensitized solar cells: effect of device masking on conversion efficiency

Seigo Ito, Md. Khaja Nazeeruddin, Paul Liska, Pascal Comte, Raphaël Charvet, Péter Péchy, Marie Jirousek, Andreas Kay, Shaik M. Zakeeruddin, Michael Grätzel

Journal:

Progress in Photovoltaics: Research and Applications

Year:

2006

Language:

english

File:

PDF, 244 KB

english, 2006

22

Synthesis of bisindolylmaleimide macrocycles

Michael R Jirousek, James R Gillig, David A Neel, Christopher J Rito, Douglas O'Bannon, William F Heath, John H McDonald III, Margaret M Faul, Leonard L Winneroski, Anita Melikian-Badalian, Matthew Ba

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 231 KB

english, 1995

23

Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets

Gennady P Samokhin, Michael R Jirousek, D.Kirk Ways, Ruth Ann Henriksen

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 170 KB

english, 1999

24

Reduction of PTP1B induces differential expression of PI3-kinase (p85α) isoforms

Cristina M. Rondinone, Jill Clampit, Rebecca J. Gum, Bradley A. Zinker, Michael R. Jirousek, James M. Trevillyan

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 1.31 MB

english, 2004

25

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells

Jill E Clampit, Joseph L Meuth, Harriet T Smith, Regina M Reilly, Michael R Jirousek, James M Trevillyan, Cristina M Rondinone

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 292 KB

english, 2003

26

Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line

Wiweka Kaszubska, H.Douglas Falls, Verlyn G Schaefer, Deanna Haasch, Leigh Frost, Paul Hessler, Paul E Kroeger, David W White, Michael R Jirousek, James M Trevillyan

Journal:

Molecular and Cellular Endocrinology

Year:

2002

Language:

english

File:

PDF, 348 KB

english, 2002

27

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat

Jeffrey F. Waring, Rita Ciurlionis, Jill E. Clampit, Sherry Morgan, Rebecca J. Gum, Robert A. Jolly, Paul Kroeger, Leigh Frost, James Trevillyan, Bradley A. Zinker, Michael Jirousek, Roger G. Ulrich,

Journal:

Molecular and Cellular Endocrinology

Year:

2003

Language:

english

File:

PDF, 1.18 MB

english, 2003

28

Nanocrystalline Titanium Oxide Electrodes for Photovoltaic Applications

Christophe J. Barbé, Francine Arendse, Pascal Comte, Marie Jirousek, Frank Lenzmann, Valery Shklover, Michael Grätzel

Journal:

Journal of the American Ceramic Society

Year:

1997

Language:

english

File:

PDF, 1.23 MB

english, 1997

29

Prostaglandin endoperoxidase 21. Covalent binding of levuglandin E2 with proteins

Robert G. Salomon, Michael R. Jirousek, Subrata Ghosh, Ram B. Sharma

Journal:

Year:

1987

Language:

english

File:

PDF, 830 KB

english, 1987

30

( S )-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1 H ,13 H -dibenzo[ e , k ]pyrrolo[3,4- h ][1,4,13]oxadiazacyclohexadecene-1,3(2 H )-dione (LY333531) and Related Analogues: Isozyme Selective Inhibitors of Protein Kinase Cβ

Jirousek, Michael R., Gillig, James R., Gonzalez, Cecile M., Heath, William F., McDonald, John H., Neel, David A., Rito, Christopher J., Singh, Upinder, Stramm, Lawrence E., Melikian-Badalian, Anita,

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 192 KB

english, 1996

31

72 A Novel Salicylate Based NF-κB Inhibitor CAT-1004 Provides Superior Efficacy and Potency Compared to 5-ASA and Is Efficacious in Multiple Rodent Models of Inflammatory Bowel Disease

Picarella, Dominic, Zimmer, Mike, Liu, Feng, Bista, Pradeep, Lee, Diana, Carney, David, Vu, Chi, Milne, Jill, Jirousek, Michael

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 218 KB

english, 2014

32

PHASE 1 SINGLE AND MULTIPLE ASCENDING DOSE STUDY OF CAT-2003, A NOVEL ACTIVATOR OF LIPOPROTEIN LIPASE, DEMONSTRATES REDUCTIONS IN POSTPRANDIAL TRIGLYCERIDES

Donovan, Joanne, Dunbar, Richard, Biernat, Lucasz, Logan, Douglas, Curtis, Michael, Mancini, Maria, Jirousek, Michael

Journal:

Journal of the American College of Cardiology

Year:

2014

Language:

english

File:

PDF, 179 KB

english, 2014

33

Targeted Overexpression of Protein Kinase C β 2 Isoform in Myocardium Causes Cardiomyopathy

Hisao Wakasaki, Daisuke Koya, Frederick J. Schoen, Michael R. Jirousek, D. Kirk Ways, Brian D. Hoit, Richard A. Walsh and George L. King

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.91 MB

english, 1997

34

Phase 1 Single and Multiple Ascending Dose Study of CAT-2003, a Novel Activator of Lipoprotein Lipase, Decreases Postprandial Triglycerides†

Donovan, Joanne M., Dunbar, Richard, Biernat, Lucasz, Logan, Douglas, Curtis, Michael, Mancini, Maria, Jirousek, Michael

Journal:

Journal of Clinical Lipidology

Year:

2014

Language:

english

File:

PDF, 152 KB

english, 2014

35

Photoredox-induced polymerization of microemulsion droplets

Graetzel, Carole K., Jirousek, Marie., Graetzel, Michael.

Journal:

Year:

1986

Language:

english

File:

PDF, 3.24 MB

english, 1986

36

Synthesis of Fluorinated Macrocyclic Bis(indolyl)maleimides as Potential 19 F NMR Probes for Protein Kinase C

Goekjian, Peter G., Wu, Guo-Zhang, Chen, Shi, Zhou, Lanxin, Jirousek, Michael R., Gillig, James R., Ballas, Lawrence M., Dixon, Jeffrey T.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 121 KB

english, 1999

37

Macrocyclic Bisindolylmaleimides: Synthesis by Inter- and Intramolecular Alkylation

Faul, Margaret M., Winneroski, Leonard L., Krumrich, Christine A., Sullivan, Kevin A., Gillig, James R., Neel, David A., Rito, Christopher J., Jirousek, Michael R.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 183 KB

english, 1998

38

Robustadials. 4. Molecular mechanics and NMR studies of conformational and configurational equilibria: 3,4-dihydrospiro[2H-1-benzopyran-2,2'-bicyclo[2.2.1]heptanes]

Jirousek, Michael R., Mazza, Samuel M., Salomon, Robert G.

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 969 KB

english, 1988

39

The Effect of Two Terminal Alkoxy Groups on the Mesomorphic Properties of 4, 4′-Disubstituted Phenylthiobenzoates

Neubert, Mary E., Ziemnicka-merchant, Barbara, Jirousek, Michael R., Laskos, Stanley J., Leonhardt, Darrin, Sharma, Ram B.

Journal:

Molecular Crystals and Liquid Crystals Incorporating Nonlinear Optics

Year:

1988

Language:

english

File:

PDF, 1014 KB

english, 1988

40

Protein kinase C inhibitors as novel anticancer drugs

Jirousek, Michael R, Goekjian, Peter G

Journal:

Expert Opinion on Investigational Drugs

Year:

2001

Language:

english

File:

PDF, 375 KB

english, 2001

41

The Effect of Carbonyl Containing Substituents in the Terminal Chains on Mesomorphic Properties in Some Aromatic Esters and Thioesters. 3. Acyloxy Groups on the Acid End

Neubert, Mary E., Colby, Cynthia, Ezenyilimba, Matthew C., Jirousek, Michael R., Leonhardt, Darrin, Leung, Katherine

Journal:

Molecular Crystals and Liquid Crystals Incorporating Nonlinear Optics

Year:

1988

Language:

english

File:

PDF, 713 KB

english, 1988

42

Mesomorphic Properties of Some 4, 4′- Alkyl and Alkoxy Disubstituted Phenylbenzoates

Neubert, Mary E., Jirousek, Michael R., Hanlon, Carol A.

Journal:

Molecular Crystals and Liquid Crystals

Year:

1986

Language:

english

File:

PDF, 356 KB

english, 1986

43

Purification of a Water-Sensitive Natural Product with an Aprotic CPC Solvent System

Jirousek, Michael R., Salomon, Robert G.

Journal:

Journal of Liquid Chromatography

Year:

1988

Language:

english

File:

PDF, 357 KB

english, 1988

44

Phase 1 Study of CAT-2054, an Oral Novel Modulator of SREBP

Donovan, Joanne M., Mancini, Maria, Sanabria, Carlos, Jirousek, Michael

Journal:

Journal of Clinical Lipidology

Year:

2015

Language:

english

File:

PDF, 52 KB

english, 2015

45

Dimer cation formation in anionic microemulsion media. Duroquinone-sensitized photooxidation of 2,6-dimethylnaphthalene and tetrathiafulvalene

Graetzel, Carole K., Kira, Akira, Jirousek, Marie, Graetzel, Michael

Journal:

Journal of Physical Chemistry

Year:

1983

Language:

english

File:

PDF, 710 KB

english, 1983

46

A Novel NF-κB Inhibitor, Edasalonexent (CAT-1004), in Development as a Disease-Modifying Treatment for Patients With Duchenne Muscular Dystrophy: Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics in Adult Subjects

Donovan, Joanne M., Zimmer, Michael, Offman, Elliot, Grant, Toni, Jirousek, Michael

Journal:

Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 464 KB

english, 2017

47

Photo-induced oxidation op N-vinylcarbazole in a functionalized oil-in-water microemulsion

Grätzel, Carole K., Jirousek, Marie, Grätzel, Michael

Journal:

Colloids and Surfaces

Year:

1985

Language:

english

File:

PDF, 537 KB

english, 1985